Only your judgments are truly under your control
The foundation of Pigliucci's Stoicism is a sorting exercise: everything in life falls into things within your control (your opinions, intentions, reactions) and things outside it (your health, your reputation, other people, the weather, the economy). Suffering, he argues, comes almost entirely from investing your sense of worth and peace in the second category while neglecting the first.
This isn't fatalism — you still act in the world, pursue goals, and care about outcomes. But the Stoic move is to hold outcomes loosely, as 'preferred' rather than 'necessary,' so that failure to achieve them doesn't collapse your equilibrium. You did your best judgment and effort; the rest was never fully yours to guarantee.
Pigliucci frames this as liberating rather than resigned: once you stop demanding control over the uncontrollable, the anxiety tied to that demand has nowhere to attach. Direct your full effort toward your choices, and hold everything else with an open hand.